■ 教育工作经历 (1) 1990/09 -1994/07,南开大学生命科学学院,理学学士; 1999/09 -2004/07,中国科学院生物物理研究所,理学博士。 (2) 2004/07 -2006/06 北京大学医学部免疫系、北京大学人类疾病基因研究中心博士后; 2006/07 -2007/12 北京大学分子医学研究所,讲师; 2007/12 -2009/12 瑞典Karolinska Institutet 分子医学与外科学系博士后; 2010.01 -2011.09 瑞典karolinska Institutet 环境医学研究所高级研究学者。 2011.10 -今 天津体育学院 ■ 学术交流经历(国内外重要学术会议、讲学、访问) 1. 厦门大学化学化工学院,讲学,2021年5月,福建厦门; 2. 儒谈线粒体系列沙龙讲座,倡导创办,线上,2020-2021; 3. 第十八次中国暨国际生物物理大会,参加,2020年11月,广东广州; 4. 线粒体与生殖发育健康研讨会,特邀主题报告,2020年10月,中国上海; 5. 2018 American College of Sports Medicine Annual Meeting,Poster,2018年5月,Minneapolis, Minnesota USA; 6. 第四届(2016)全国运动生理与生物化学学术会议,分会报告,2016年10月,江苏无锡 7. 第12届亚洲线粒体生物医学及研究学会国际会议暨第六届中国线粒体学会学术会议,分会报告,2015年11月,浙江杭州; 8. 2015年中国生理学会运动生理学专业委员会会议暨“运动与心血管保护”学术研讨会,分会报告,2015年9月,陕西西安; 9. NAPA2014:5th International Conference on Nutrition and Physical Activity on Aging,Obesity and Cancer,分会报告,2014年11月,陕西西安; 10. 第四届天津(北方)国际心脏学术会议暨天津市医学会心血管病学分会年会,特邀报告,2014年6月,天津; 11.The 9th conference of the Asian society of mitochondrial research and medicine & the 5th conference of Chinese society of mitochondrial research and medicine, 分会报告,2012年11月, 北京; 12.Nobel Symposium: The cell cycle and apoptosis in Disease,会议秘书,2010年5月,Stockholm,Sweden; 13.The seventh European Meeting on Mitochondrial Pathology- From basic mechanisms to disease and ageing,会议报告,2008年6月,Stockholm,Sweden ■ 学术与社会兼职 (1)中国解剖学会运动解剖学分会常务委员; (2)中国生物物理学会体育医学分会委员; (3)天津心脏协会基础专委会常务委员; (4)天津细胞生物学会理事; (5)天津生理学会理事。 ■ 课题研究 (1)有氧运动通过miRNAs的转录后调控干预大鼠压力负荷致心衰进程的机制研究,国家级,国家自然科学基金面上项目(31971100),2020-2023,主持; (2)有氧运动干预压力负荷致心衰过程的分子机制研究,省部级,天津市应用基础与前沿技术研究计划(13JCYBJC39200),2013-2016,主持; (3)运动干预心衰进程中线粒体超氧炫及膜通透性调控, 国家级,国家重点基础研究发展计划(973)项目《线粒体功能障碍致早期心衰机制及干预策略研究》(2013CB531201)子课题,2013-2017,主持。 ■ 核心刊物论文发表 1. Wang S, Li J, Zhao Y*. Construction and analysis of a network of exercise-induced mitochondria-related non-coding RNA in the regulation of diabetic cardiomyopathy. PLoS ONE, 2024,19(3): e0297848 2. 姬卫秀,白毅,王硕,赵云罡*. 3-硝基-N- 甲基水杨酰胺对肢体缺血再灌注损伤大鼠骨骼肌的保护作用及机制. 中国组织工程研究,2024,28(20):3164-3169 3. 姬卫秀,耿燚,王硕,赵云罡*.线粒体在运动保护心肌免受缺血再灌注损伤中的作用. 生物物理与生物化学进展. 2024,5: 4. Wang S, Liu W, Liu S, Li J, Geng Y, Zhao Y*. Improved cardioprotective effect of 3-nitro-N-methyl salicylamide solution after a prolonged preservation time of rat heart. Clin Exp Pharmacol Physiol. 2023:1–9. 5. Li M, Gao Z, Wang S, Zhao Y*, Xie H*. miR‑27a‑3p upregulation by p65 facilitates cervical tumorigenesis by increasing TAB3 expression and is involved in the positive feedback loop of NF‑κB signaling. Oncology Reports. 2023, 50: 132 6. 王硕,赵云罡*. 心衰进程中非编码RNA对线粒体功能的调控作用. 生物物理与生物化学进展,2023,50(7),1538-1552 7. Yuan M, Gong M, He J, Xie B, Zhang Z, Meng L, Tse G, Zhao Y, Bao Q, Zhang Y, Yuan M, Liu X, Luo C, Wang F, Li G, Liu T. IP3R1/GRP75/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling. Redox Biology. 2022,52:102289 8. 王硕,刘文英,吕超凡,李佳聪,耿燚,赵云罡*. 含3-硝基-N- 甲基水杨酰胺的新型保护液对冷缺血保存离体大鼠心脏的保护. 中国组织工程研究,2022,26(8):1194-1201 9. Zhang Z, Zhang X, Meng L, Gong M, Li J, Shi W, Qiu J, Yuan Y, Zhao J, Suo Y, Liang X, Wang X, Tse G, Jiang N, Li G, Zhao Y*, Liu T*. Pioglitazone Inhibits Diabetes-Induced Atrial Mitochondrial Oxidative Stress and Improves Mitochondrial Biogenesis, Dynamics, and Function Through the PPAR-γ/PGC-1α Signaling Pathway. Frontiers in Pharmacology. 2022,12:658362(并列通讯作者). 10. Hu C, Shu L, Huang X, Yu J, Li L, Gong L, Yang M, Wu Z, Gao Z, Zhao Y, Chen L, Song Z. OPA1 and MICOS Regulate mitochondrial crista dynamics and formation. Cell Death and Disease.2020, 11:940-957. 11. Yuan M, Gong M, Zhang Z, Meng L, Tse G, Zhao Y, Bao Q, Zhang Y, Yuan M, Liu X, Li G, Liu T. Hyperglycemia Induces Endoplasmic Reticulum Stress in Atrial Cardiomyocytes, and Mitofusin-2 Downregulation Prevents Mitochondrial Dysfunction and Subsequent Cell Death. Oxidative Medicine and Cellular Longevity. 2020, Article ID 6569728. 12. Gong M, Yuan M, Meng L, Zhang Z, Tse G, Zhao Y, Zhang Y, Yuan M, Liang X, Fan G, Yan GX, Li G, Liu T. Wenxin Keli Regulates Mitochondrial Oxidative Stress and Homeostasis and Improves Atrial Remodeling in Diabetic Rats. Oxid Med Cell Longev. 2020, 2020:2468031. 13. Wang Y, Bi C, Pang W, Liu Y, Yuan Y, Zhao H, Zhang T, Zhao Y*, Li Y*. Plasma Metabolic Profiling Analysis of Gout Party on Acute Gout Arthritis Rats Based on UHPLC-Q-TOF/MS Combined with Multivariate Statistical Analysis. Int J Mol Sci. 2019, 20(22):5753 (并列通讯作者). 14. Shao Q, Meng L, Lee S, Tse G, Gong M, Zhang Z, Zhao J, Zhao Y, Li G, Liu T. Empagliflozin, a sodium glucose co-transporter-2 inhibitor, alleviates atrial remodeling and improves mitochondrial function in high-fat diet/streptozotocin-induced diabetic rats. Cardiovasc Diabetol. 2019, 18(1):165. 15. 丁虎, 张勇, 赵云罡*. 线粒体在运动诱导骨骼肌适应过程中的应答机制. 生理科学进展, 2018, 49(1): 28~34 16. Zhang X, Zhang Z, Yang Y, Suo Y, Liu R, Qiu J, Zhao Y, Jiang N, Liu C, Tse G, Li G, Liu T. Alogliptin prevents diastolic dysfunction and preserves left ventricular mitochondrial function in diabetic rabbits. Cardiovasc Diabetol. 2018, 17(1):160. 17. Dong A, Yu Y, Wang Y, Li C, Chen H, Bian Y, Zhang P, Zhao Y, Yu Y, Xie K. Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics. Int Immunopharmacol. 2018, 65:366-372. 18. Zhang X, Zhang Z, Zhao Y, Jiang N, Qiu J, Yang Y, Li J, Liang X, Wang X, Tse G, Li G, Liu T. Alogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Alleviates Atrial Remodeling and Improves Mitochondrial Function and Biogenesis in Diabetic Rabbits. J Am Heart Assoc. 2017, 6(5):e005945. 19. 赵云罡, 李灿, 丁树哲, 张勇. 线粒体质量控制:运动促进健康与预防疾病的靶向. 生理科学进展. 2014, 45(5): 327-331. 20. Hong Xie, Yungang Zhao, Stefano Caramuta, Catharina Larsson, Weng-Onn Lui. miR-205 Expression Promotes Cell Proliferation and Migration of Human Cervical Cancer Cells. PLOS One. 2012, 7(10): e46990-e46990. 21. Zhao T, Huang X, Han L, Wang X, Cheng H, Zhao Y, Chen Q, Chen J, Cheng H, Xiao R, Zheng M. Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes. J Biol. Chem. 2012, 287(28): 23615-23625. 22. Zhao Y, Xu J-X. The operation of the alternative electron-leak pathways mediated by cytochrome c in mitochondria. Biochem. Biophys. Res. Commu. 2004, 317(4): 980-987. 23. Zhao Y, Wang Z-B, Xu J-X. Effect of cytochrome c on the generation and elimination of O2-. and H2O2 in mitochondria. J Biol. Chem. 2002, 278(4): 2356-2360. 24. Wang Z-B, Li M, Zhao Y, Xu J-X. Cytochrome c is a hydrogen peroxide scavenger in mitochondria. Pro. Pep. Lett. 2003, 10(3): 247-253. 25. Zhao Y, Xu J-X, Mitochondria, reactive oxygen species and apoptosis, Prog. Biochem. Biophys. 2001; 28 (2): 168-171. ■ 主要著作 ■ 成果获奖情况
■ 培养研究生要求 对细胞与分子生物运动生理学具有浓厚兴趣,对世界有足够的好奇心;有较好的中文写作能力;诚实可信,严谨求实,有眼缘。 |