■ 学科(专业)：体育学（运动人体科学）

■ 主要研究方向：(限二个方向) 运动生理学，分子遗传学

■ 教育工作经历

1991.9--1997.6   天津南开中学

1997.9--2001.6   天津南开大学生命科学院获得微生物学学士学位

2002.9--2003.8   英国爱丁堡大学医学院获得生命科学硕士学位

2003.9—2011.2   美国纽约州立大学布法罗分校硕博连读，获得分子与细胞生物学硕士和博士学位

2011.4—2014.3   美国Roswell Park癌症研究中心博士后研究员

2014.4—2016.3   美国匹兹堡大学医学院博士后研究员

2016.4—今       天津市体育学院研究员 

■ 学术交流经历(国内外重要学术会议、讲学、访问)

1. 2009.04, 第100届美国癌症研究学会年会（The 100^th American Association for Cancer Research Annual Meeting），美国丹佛。 Lei Quan, Peter Demant：Genetics of location of tumors in an organ: A mouse lung cancer susceptibility gene affecting predominantly or only peribronchial tumors（墙报）。

2. 2012.04, 第102届美国癌症研究学会年会（The 102^th American Association for Cancer Research Annual Meeting），美国芝加哥。 Lei Quan et al.: Cytokine and cytokine receptors of adaptive immune response are differentially associated with breast cancer risk in women of African Ancestry and European Ancestry （墙报）。

3. 2016.10, 中国运动生理与生物化学学术会议，中国无锡。

4. 2017.09, The 8th Biennial Meetings of Society for Free Radical Research-Asia (SFRR-Asia) & The 14th Conference of the Asia Society of Mitochondrial Research and Medicine (ASMRM), 中国西安。

5. 2018.08, 天津康复医学综合学术论坛，中国天津。

6. 2018.10, The 17^th International Biochemistry of Exercise Conference, 中国北京。

7. 2019.03, 第110届美国癌症研究学会年会（The 110^th American Association for Cancer Research Annual Meeting），美国亚特兰大。Quan Lei， Alan Hutson， Peter Demant：Robust evolutionary conservation and pair-wise co-mapping of polygenic colon and lung cancer susceptibility loci（墙报）。

8. 2020.08,中国生理学会学术年会，线上会议。郭文平，王艾佳，权磊：Dusp基因家族与肺癌、大肠癌和胃癌的关联性分析（墙报）。

■ 学术与社会兼职

中国解剖学会会员 Chinese Society for Anatomical Sciences (CSAS)

美国癌症研究协会会员American Association for Cancer Research (AACR)

美国人类遗传学协会会员American Society of Human Genetics (ASHG)

国际期刊审稿人：International Journal of Cancer， Carcinogenesis，

Plos ONE,  Frontier of Epidemiology,  Mutation Research

■ 课题研究

1. 2008–2012, 美国国家健康院(National Institutes of Health), R01CA116158, Relationship of Colon and Lung Cancer Susceptibility Genes, 主持人：Dr. Peter Demant, 总金额:1,250,000美元, 主要完成人。

2. 2011–2015, 美国国家健康院(National Institutes of Health), R01CA127162, Host’s Genes that Control Lymphocyte Infiltration of Tumors, 主持人：Dr. Peter Demant, 总金额: 760,000美元, 主要完成人。

3. 2009-2013,美国国防部 (Department of Defense), BC094862, Genetic and Functional Dissection of Susceptibility to Her-2/neu-Mediated Mammary Tumors,  主持人：Dr. Peter Demant, 总金额: 360,000美元, 主要完成人。

4. 2008–2012, 美国国家健康院(National Institutes of Health), R01CA100598, Race and Risk Factors for Early/ Aggressive Breast Cancer, 主持人：Dr. Christine Ambrosone, 总金额: 5,800,000美元, 参与人员。

5. 2016–今  天津市自然科学基金绿色通道项目，16JCYBJC42900 ，肺癌易感基因Sluc20和大肠癌易感基因Scc8的关联性研究，总金额：10万元人民币，主持人。

■ 核心刊物论文发表

1. Quan L, Hutson A, Demant P*.Cross-Cancer Analysis Reveals Novel Pleiotropic Associations. Cancer Research, 77(21):6042-6044, 2017. （IF=9.1）

2. Quan L, Gong Z, Yao S, Bandera EV, Zirpoli G, Hwang F, Roberts M, Ciupak G, Davis W, Sucheston L, Pawlish K, Jandorf K, Bovbjerg D, Ambrosone CB, Hong CC*. Cytokine and cytokine receptor genes of adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry. International Journal of Cancer, 134(6), 1408-21, 2014. （IF=6.2）

3. Quan L, Hong CC, Zirpoli G, Bandera EV, Roberts M, Coignet J, Cabasag C, Sucheston L, Hwang H, Ciupak G, Davis W, Pawlish K, Jandorf L, Bovbjerg D, Ambrosone CB, Yao S*. Variants in estrogen-related genes and breast cancer risk in European and African American women. Endocrine-Related Cancer, 21(6):853-64, 2014. （IF=5.2）

4. Yao S*, Hong CC, McCann SE, Zirpoli G, Quan L, Gong Z, Johnson CS, Trump DL, Ambrosone CB. Combined Effects of Circulating Levels of 25-Hydroxyvitamin D and Th1 and Th2 Cytokines on Breast Cancer Estrogen Receptor Status. Cancers, 6(1), 211-25, 2014.

5. Gong Z*, Quan L, Yao S, Zirpoli G, Bandera EV, Roberts M, Coignet J, Cabasag C, Sucheston L, Hwang H, Ciupak G, Davis W, Pawlish K, Jandorf L, Bovbjerg D, Ambrosone CB, Hong CC. Innate immunity pathways and breast cancer risk in African American and European-American women in the women's circle of health study (WCHS). PLoS One, 8(8), e72619, 2013.

6. Hong CC*, Yao S, McCann SE, Dolnick RY, Wallace PK, Gong Z, Quan L, Lee KP, Evans SS, Repasky EA, Edge SB, Ambrosone CB. Pretreatment levels of circulating Th1 and Th2 cytokines, and their ratios, are associated with ER-negative and triple negative breast cancers. Breast Cancer Research and Treatment, 139(2), 477-88, 2013.

7. Quan L, Dittmar A, Zhou Y, Hutson A, Stassen APM, Demant P*. Susceptibility loci affecting ErbB2/neu-induced mammary tumorigenesis and metastasis in mice. Gene Chromosome Canc, 51(7), 631-43, 2012. （IF=3.9）

8. Quan L, Stassen AP, Ruivenkamp CL, Fijneman RJ, Hutson AA, Hart AM, Demant P*. Most lung and colon cancer susceptibility genes are pair-wise linked in mice, humans and rats. PLoS One, 6(2), e14727, 2011. （IF=3.7）

9. Havelková H, Svobodová M, Quan L, Jarošíková T, Vojtíšková J, Stassen AP, Demant P, Lipoldová M*. Genetic control of resistance to Trypanosoma brucei brucei infection in mice. Plos Neglect Trop D , 5(6), e1173 , 2011.

10. Piskorowaska J, Gajewska M, Szymanska H, Krysiak E, Quan L, Grygalewicz B, Skurzak HM, Czarnomska A, Pienkowska-Grela B, Demant P*. Susceptibility loci and chromosomal abnormalities in radiation induced hematopoietic neoplasms in mice. Journal of Radiation Research, 52(2):147-58, 2011.

11. Quan L, Hutson A, and Demant P*. A locus on chromosome 8 controlling tumor regionality：a new type of tumor diversity in the mouse lung. International Journal of Cancer, 126(11):2603-13, 2010. （IF=6.2）

12. Lipoldová M, Havelková H, Badalová J, Vojtíšková J, Quan L, Krulová M, Sohrabi Y, Stassen AP, Demant P*. Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility. Cancer Immunology Immunotherapy, 59:203-13, 2010.

13. Kurey I, Kobets T, Havelková H, Slapnicková M, Quan L, Trtková K, Grekov I, Svobodová M, Stassen AP, Hutson A, Demant P, Lipoldová M*. Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Immunogenetics, 61(9):619-33, 2009.

14. Kakarlapudi N, Vernooy JH, Quan L, Fijneman RJ, Demant P*. Control of lymphocyte infiltration of lung tumors in mice by host's genes: mapping of four Lynf (lymphocyte infiltration) loci. Cancer Immunology Immunotherapy, 57(2):217-25, 2008.

15. Varga AE, Stourman NV, Zheng Q, Safina AF, Quan L, Li X, Sossey-Alaoui K, Bakin AV*. Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta. Oncogene, 24(32):5043-52, 2005.

*为通讯作者

■ 主要著作

无

■ 成果获奖情况

无

■ 培养研究生要求

热爱科学研究，具有较强的事业心和责任感，具有良好的道德品质和学术修养。